Analytical characterization
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Analytical characterization
We take up end to end characterization of industrial products like proteins, peptides or NCEs used as therapeutic drugs on instruments like QTOF, MALDI, NMR, MALS etc
- Molecular weight, Exact Mass by ESI-LC-QTOF
- Partial, Complete and Denovo sequencing by ESI-LC-QTOF and MALDI
- Purity check by UHPLC/HPLC
- Quantitative Amino Acid composition analysis by ESI-LC-Q3
- Post Translational Modification (sulphation, acetylation, methylation, phosphorylation, glycation, pegylaion etc) site and structure analysis by ESI-LC-QTOF
- Elemental analysis by ICP-MS
- Protein and Impurity Profiling by ESI-LC-QTOF
- Lable free and Labelled quantitation of proteins and metabolites by ESI-LC-QTOF
- Absolute and relative quantification of Metabolites by ESI-LC-Q3
- Nucleotide purity and sequencing analysis DNA/RNA etc by MALDI and ESI-LC-QTOF
- Host Cell Protein analysis by host DNA estimation and DIGE 2DE analysis.
- Secondary structure by Circular Dichroism and Fluoresence Spetroscopy
- Higher order structure by 1D H1-NMR by 500MHz or 700MHz, C13-NMR, 2D-H1 NMR by COSY(Correlation Spectroscopy). TOCSY (Total correlation Spectroscopy), NOESY(Nuclear over hauser effect spectroscopy), HSQC (Heteronuclear single quantum coherence spectroscopy), DOSY( Diffusion ordered spectroscopy), ROESY( Rotating nuclear over hauser spectroscopy)
- Higher order structure by X-Ray Diffractometer
- Thermal analysis Thermo gravimetric analyser
- Fourier Transformer Infrared Spectroscopy (FTIR)
- Differential fluorometric analysis by Confocal Microscopy
- Atomic Absorption spectroscopy
- Molecular weight, purity, aggregation and isoelectric point analysis by Capillary Electrophoresis and Iso Electric focusing
